Drug interactions
Amlodipine + Labetalol
Severity: Minor
Amlodipine and Labetalol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining labetalol with the dihydropyridine amlodipine gives additive blood pressure lowering. This combination is commonly used therapeutically, but hypotension may occur on initiation.
What this interaction means in plain words
Amlodipine and Labetalol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine belongs to Cardiovascular; Labetalol belongs to Cardiovascular.
Why it happens
Additive vasodilation and antihypertensive effect via alpha/beta blockade and calcium channel blockade.
What to do
Monitor blood pressure and titrate doses gradually.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Other interactions of Amlodipine
- Amifostine + Amlodipine Major
- Amlodipine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Activated Charcoal + Amlodipine Moderate
- Aldesleukin + Amlodipine Moderate
- Alfuzosin + Amlodipine Moderate
- Amlodipine + Apalutamide Moderate
Frequently asked questions
Can I take Amlodipine with Labetalol?
MediHelp rates the interaction as minor. Amlodipine and Labetalol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Combining labetalol with the dihydropyridine amlodipine gives additive blood pressure lowering. This combination is commonly used therapeutically, but hypotension may occur on initiation.
How serious is the interaction between Amlodipine and Labetalol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and titrate doses gradually.
What other medicines interact with Labetalol?
MediHelp also lists interactions of Labetalol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Labetalol page.
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