Drug interactions
Amlodipine + Lomitapide
Severity: Moderate
Amlodipine and Lomitapide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amlodipine is a weak CYP3A4 inhibitor and may raise lomitapide levels. Greater lomitapide exposure increases the risk of hepatotoxicity and gastrointestinal adverse effects.
What this interaction means in plain words
Amlodipine and Lomitapide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine belongs to Cardiovascular; Lomitapide belongs to Cardiovascular.
Why it happens
Weak CYP3A4 inhibition by amlodipine reduces lomitapide metabolism.
What to do
Limit the lomitapide dose to 30 mg daily when used with weak CYP3A4 inhibitors per labeling. Monitor liver enzymes and tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine
- Amifostine + Amlodipine Major
- Amlodipine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Activated Charcoal + Amlodipine Moderate
- Aldesleukin + Amlodipine Moderate
- Alfuzosin + Amlodipine Moderate
- Amlodipine + Apalutamide Moderate
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Amlodipine with Lomitapide?
MediHelp rates the interaction as moderate. Amlodipine and Lomitapide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amlodipine is a weak CYP3A4 inhibitor and may raise lomitapide levels. Greater lomitapide exposure increases the risk of hepatotoxicity and gastrointestinal adverse effects.
How serious is the interaction between Amlodipine and Lomitapide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit the lomitapide dose to 30 mg daily when used with weak CYP3A4 inhibitors per labeling. Monitor liver enzymes and tolerability.
What other medicines interact with Amlodipine?
MediHelp also lists interactions of Amlodipine with, for example, Amifostine, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Activated Charcoal. The full list is on the Amlodipine page.
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