Drug interactions
Amlodipine + Lurasidone
Severity: Moderate
Amlodipine and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lurasidone has alpha-1 adrenergic blocking activity that can cause orthostatic hypotension, which may add to the blood pressure lowering of amlodipine. Dizziness, syncope and falls are the main concerns, particularly at initiation or with dose increases.
What this interaction means in plain words
Amlodipine and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine belongs to Cardiovascular; Lurasidone belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic hypotensive effects from alpha-1 blockade and calcium channel blockade.
What to do
Monitor blood pressure and orthostatic symptoms when starting or adjusting lurasidone. Reduce the antihypertensive dose if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine
- Amifostine + Amlodipine Major
- Amlodipine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Activated Charcoal + Amlodipine Moderate
- Aldesleukin + Amlodipine Moderate
- Alfuzosin + Amlodipine Moderate
- Amlodipine + Apalutamide Moderate
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Amlodipine with Lurasidone?
MediHelp rates the interaction as moderate. Amlodipine and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lurasidone has alpha-1 adrenergic blocking activity that can cause orthostatic hypotension, which may add to the blood pressure lowering of amlodipine. Dizziness, syncope and falls are the main concerns, particularly at initiation or with dose increases.
How serious is the interaction between Amlodipine and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or adjusting lurasidone. Reduce the antihypertensive dose if hypotension occurs.
What other medicines interact with Amlodipine?
MediHelp also lists interactions of Amlodipine with, for example, Amifostine, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Activated Charcoal. The full list is on the Amlodipine page.
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