Drug interactions
Amlodipine + Mefloquine
Severity: Minor
Amlodipine and Mefloquine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mefloquine may have additive effects on cardiac conduction with calcium channel blockers, and amlodipine exposure could theoretically rise. Clinically significant effects are uncommon with amlodipine, which has little effect on conduction.
What this interaction means in plain words
Amlodipine and Mefloquine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine belongs to Cardiovascular; Mefloquine belongs to Anti Parasitic.
Why it happens
Possible additive effects on cardiac conduction; a pharmacokinetic effect on amlodipine is not well established.
What to do
Monitor blood pressure and heart rate when the two are combined. Check an ECG if the patient has conduction disease.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Other interactions of Amlodipine
- Amifostine + Amlodipine Major
- Amlodipine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Activated Charcoal + Amlodipine Moderate
- Aldesleukin + Amlodipine Moderate
- Alfuzosin + Amlodipine Moderate
- Amlodipine + Apalutamide Moderate
Frequently asked questions
Can I take Amlodipine with Mefloquine?
MediHelp rates the interaction as minor. Amlodipine and Mefloquine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mefloquine may have additive effects on cardiac conduction with calcium channel blockers, and amlodipine exposure could theoretically rise. Clinically significant effects are uncommon with amlodipine, which has little effect on conduction.
How serious is the interaction between Amlodipine and Mefloquine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when the two are combined. Check an ECG if the patient has conduction disease.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
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