Drug interactions
Amlodipine + Nitroglycerin
Severity: Moderate
Amlodipine and Nitroglycerin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitroglycerin and amlodipine both dilate blood vessels, so together they can cause additive hypotension, dizziness and orthostatic symptoms. The combination is commonly used in angina and is usually well tolerated.
What this interaction means in plain words
Amlodipine and Nitroglycerin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine belongs to Cardiovascular; Nitroglycerin belongs to Cardiovascular.
Why it happens
Additive vasodilation through nitric oxide-mediated venous dilation and calcium channel blocker arterial dilation.
What to do
Counsel patients to sit when taking sublingual nitroglycerin and to rise slowly; monitor blood pressure after starting or increasing either drug.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nitroglycerin
- Avanafil + Nitroglycerin Contraindicated
- Nitroglycerin + Riociguat Contraindicated
- Nitroglycerin + Sildenafil Contraindicated
- Nitroglycerin + Tadalafil Contraindicated
- Nitroglycerin + Vardenafil Contraindicated
- Dihydroergotamine intranasal + Nitroglycerin Major
Other interactions of Amlodipine
- Amifostine + Amlodipine Major
- Amlodipine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Activated Charcoal + Amlodipine Moderate
- Aldesleukin + Amlodipine Moderate
- Alfuzosin + Amlodipine Moderate
- Amlodipine + Apalutamide Moderate
Frequently asked questions
Can I take Amlodipine with Nitroglycerin?
MediHelp rates the interaction as moderate. Amlodipine and Nitroglycerin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nitroglycerin and amlodipine both dilate blood vessels, so together they can cause additive hypotension, dizziness and orthostatic symptoms. The combination is commonly used in angina and is usually well tolerated.
How serious is the interaction between Amlodipine and Nitroglycerin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to sit when taking sublingual nitroglycerin and to rise slowly; monitor blood pressure after starting or increasing either drug.
What other medicines interact with Nitroglycerin?
MediHelp also lists interactions of Nitroglycerin with, for example, Avanafil, Riociguat, Sildenafil. The full list is on the Nitroglycerin page.
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