Drug interactions
Amlodipine + Ribociclib
Severity: Moderate
Amlodipine and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib is a moderate CYP3A4 inhibitor and may increase amlodipine exposure, potentiating hypotension and edema. The effect is usually moderate and manageable.
What this interaction means in plain words
Amlodipine and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine belongs to Cardiovascular; Ribociclib belongs to Oncology.
Why it happens
Ribociclib inhibits CYP3A4, decreasing amlodipine metabolism.
What to do
Monitor blood pressure and peripheral edema during ribociclib treatment, and reduce the amlodipine dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine
- Amifostine + Amlodipine Major
- Amlodipine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Activated Charcoal + Amlodipine Moderate
- Aldesleukin + Amlodipine Moderate
- Alfuzosin + Amlodipine Moderate
- Amlodipine + Apalutamide Moderate
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Amlodipine with Ribociclib?
MediHelp rates the interaction as moderate. Amlodipine and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribociclib is a moderate CYP3A4 inhibitor and may increase amlodipine exposure, potentiating hypotension and edema. The effect is usually moderate and manageable.
How serious is the interaction between Amlodipine and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and peripheral edema during ribociclib treatment, and reduce the amlodipine dose if needed.
What other medicines interact with Amlodipine?
MediHelp also lists interactions of Amlodipine with, for example, Amifostine, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Activated Charcoal. The full list is on the Amlodipine page.
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