Drug interactions
Amlodipine + Tacrolimus
Severity: Moderate
Amlodipine and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amlodipine is a weak CYP3A4 inhibitor and has been associated with increased tacrolimus blood concentrations in transplant patients. Higher tacrolimus levels can increase the risk of nephrotoxicity, neurotoxicity and hyperglycemia.
What this interaction means in plain words
Amlodipine and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine belongs to Cardiovascular; Tacrolimus belongs to Miscellaneous.
Why it happens
Amlodipine weakly inhibits CYP3A4 and possibly intestinal P-glycoprotein, reducing tacrolimus clearance.
What to do
Measure tacrolimus trough levels and renal function after starting or stopping amlodipine, and adjust the tacrolimus dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine
- Amifostine + Amlodipine Major
- Amlodipine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Activated Charcoal + Amlodipine Moderate
- Aldesleukin + Amlodipine Moderate
- Alfuzosin + Amlodipine Moderate
- Amlodipine + Apalutamide Moderate
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Amlodipine with Tacrolimus?
MediHelp rates the interaction as moderate. Amlodipine and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amlodipine is a weak CYP3A4 inhibitor and has been associated with increased tacrolimus blood concentrations in transplant patients. Higher tacrolimus levels can increase the risk of nephrotoxicity, neurotoxicity and hyperglycemia.
How serious is the interaction between Amlodipine and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Measure tacrolimus trough levels and renal function after starting or stopping amlodipine, and adjust the tacrolimus dose as needed.
What other medicines interact with Amlodipine?
MediHelp also lists interactions of Amlodipine with, for example, Amifostine, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Activated Charcoal. The full list is on the Amlodipine page.
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