Drug interactions
Amlodipine + Tazemetostat
Severity: Minor
Amlodipine and Tazemetostat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a weak-to-moderate CYP3A inducer and may modestly lower amlodipine levels. Amlodipine, a weak CYP3A inhibitor, could slightly raise tazemetostat exposure, though the clinical effects of both are likely small.
What this interaction means in plain words
Amlodipine and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine belongs to Cardiovascular; Tazemetostat belongs to Miscellaneous.
Why it happens
Bidirectional CYP3A modulation: induction by tazemetostat and weak inhibition by amlodipine.
What to do
Monitor blood pressure for reduced amlodipine effect and monitor tazemetostat tolerability. Adjust amlodipine if control is lost.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine
- Amifostine + Amlodipine Major
- Amlodipine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Activated Charcoal + Amlodipine Moderate
- Aldesleukin + Amlodipine Moderate
- Alfuzosin + Amlodipine Moderate
- Amlodipine + Apalutamide Moderate
Other interactions of Tazemetostat
Frequently asked questions
Can I take Amlodipine with Tazemetostat?
MediHelp rates the interaction as minor. Amlodipine and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tazemetostat is a weak-to-moderate CYP3A inducer and may modestly lower amlodipine levels. Amlodipine, a weak CYP3A inhibitor, could slightly raise tazemetostat exposure, though the clinical effects of both are likely small.
How serious is the interaction between Amlodipine and Tazemetostat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure for reduced amlodipine effect and monitor tazemetostat tolerability. Adjust amlodipine if control is lost.
What other medicines interact with Amlodipine?
MediHelp also lists interactions of Amlodipine with, for example, Amifostine, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Activated Charcoal. The full list is on the Amlodipine page.
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