Drug interactions
Amlodipine-atorvastatin + Efavirenz
Severity: Moderate
Amlodipine-atorvastatin and Efavirenz: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz induces CYP3A4 and can lower amlodipine and atorvastatin concentrations. This may reduce blood pressure control and lipid-lowering effect.
What this interaction means in plain words
Amlodipine-atorvastatin and Efavirenz can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-atorvastatin belongs to Cardiovascular; Efavirenz belongs to Anti Virals.
Why it happens
Efavirenz induction of CYP3A4 increases metabolism of amlodipine and atorvastatin.
What to do
Monitor blood pressure and lipid levels, and increase amlodipine or atorvastatin doses as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-atorvastatin
Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Amlodipine-atorvastatin with Efavirenz?
MediHelp rates the interaction as moderate. Amlodipine-atorvastatin and Efavirenz can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Efavirenz induces CYP3A4 and can lower amlodipine and atorvastatin concentrations. This may reduce blood pressure control and lipid-lowering effect.
How serious is the interaction between Amlodipine-atorvastatin and Efavirenz?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and lipid levels, and increase amlodipine or atorvastatin doses as needed.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Atazanavir. The full list is on the Amlodipine-atorvastatin page.
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