Drug interactions
Amlodipine-atorvastatin + Ivosidenib
Severity: Moderate
Amlodipine-atorvastatin and Ivosidenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib induces CYP3A4 and may lower concentrations of amlodipine and atorvastatin. This can reduce blood pressure control and lipid-lowering efficacy.
What this interaction means in plain words
Amlodipine-atorvastatin and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-atorvastatin belongs to Cardiovascular; Ivosidenib belongs to Oncology.
Why it happens
CYP3A4 induction increases metabolism of amlodipine and atorvastatin.
What to do
Monitor blood pressure and lipid profile and adjust doses or add alternative agents if efficacy is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-atorvastatin
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Amlodipine-atorvastatin with Ivosidenib?
MediHelp rates the interaction as moderate. Amlodipine-atorvastatin and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivosidenib induces CYP3A4 and may lower concentrations of amlodipine and atorvastatin. This can reduce blood pressure control and lipid-lowering efficacy.
How serious is the interaction between Amlodipine-atorvastatin and Ivosidenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and lipid profile and adjust doses or add alternative agents if efficacy is lost.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Atazanavir. The full list is on the Amlodipine-atorvastatin page.
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