Drug interactions
Amlodipine-atorvastatin + Lofexidine
Severity: Moderate
Amlodipine-atorvastatin and Lofexidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofexidine is a central alpha-2 agonist that lowers blood pressure and heart rate, and amlodipine adds to the blood pressure lowering. The combination can cause hypotension, dizziness and syncope. Bradycardia is mainly due to lofexidine.
What this interaction means in plain words
Amlodipine-atorvastatin and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-atorvastatin belongs to Cardiovascular; Lofexidine belongs to Central Nervous System.
Why it happens
Additive hypotensive pharmacodynamic effects of central sympatholytic action and calcium channel blockade.
What to do
Monitor blood pressure and pulse, especially during lofexidine initiation and dose changes. Hold or reduce amlodipine if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-atorvastatin
Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Frequently asked questions
Can I take Amlodipine-atorvastatin with Lofexidine?
MediHelp rates the interaction as moderate. Amlodipine-atorvastatin and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofexidine is a central alpha-2 agonist that lowers blood pressure and heart rate, and amlodipine adds to the blood pressure lowering. The combination can cause hypotension, dizziness and syncope. Bradycardia is mainly due to lofexidine.
How serious is the interaction between Amlodipine-atorvastatin and Lofexidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and pulse, especially during lofexidine initiation and dose changes. Hold or reduce amlodipine if symptomatic hypotension occurs.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Atazanavir. The full list is on the Amlodipine-atorvastatin page.
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