Drug interactions
Amlodipine-atorvastatin + Nilotinib
Severity: Moderate
Amlodipine-atorvastatin and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib inhibits CYP3A4 and may increase amlodipine and atorvastatin concentrations. Nilotinib also prolongs the QT interval, and statins may add to the risk of muscle toxicity at higher exposure.
What this interaction means in plain words
Amlodipine-atorvastatin and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-atorvastatin belongs to Cardiovascular; Nilotinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4 by nilotinib reduces the metabolism of amlodipine and atorvastatin.
What to do
Monitor blood pressure and for muscle symptoms, and follow ECG and electrolyte monitoring for nilotinib. Consider a lower statin dose if myopathy symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-atorvastatin
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Amlodipine-atorvastatin with Nilotinib?
MediHelp rates the interaction as moderate. Amlodipine-atorvastatin and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib inhibits CYP3A4 and may increase amlodipine and atorvastatin concentrations. Nilotinib also prolongs the QT interval, and statins may add to the risk of muscle toxicity at higher exposure.
How serious is the interaction between Amlodipine-atorvastatin and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and for muscle symptoms, and follow ECG and electrolyte monitoring for nilotinib. Consider a lower statin dose if myopathy symptoms appear.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Atazanavir. The full list is on the Amlodipine-atorvastatin page.
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