Drug interactions
Amlodipine-atorvastatin + Primidone
Severity: Moderate
Amlodipine-atorvastatin and Primidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Primidone is metabolized to phenobarbital and induces CYP3A4, which may lower amlodipine and atorvastatin levels. This can reduce antihypertensive and lipid-lowering efficacy.
What this interaction means in plain words
Amlodipine-atorvastatin and Primidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-atorvastatin belongs to Cardiovascular; Primidone belongs to Central Nervous System.
Why it happens
CYP3A4 induction by primidone and its phenobarbital metabolite increases drug clearance.
What to do
Monitor blood pressure and lipids and raise doses if needed. Reassess after primidone is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-atorvastatin
Other interactions of Primidone
- Lorlatinib + Primidone Contraindicated
- Lurasidone + Primidone Contraindicated
- Primidone + Ranolazine Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Voriconazole Contraindicated
- Abiraterone + Primidone Major
Frequently asked questions
Can I take Amlodipine-atorvastatin with Primidone?
MediHelp rates the interaction as moderate. Amlodipine-atorvastatin and Primidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Primidone is metabolized to phenobarbital and induces CYP3A4, which may lower amlodipine and atorvastatin levels. This can reduce antihypertensive and lipid-lowering efficacy.
How serious is the interaction between Amlodipine-atorvastatin and Primidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and lipids and raise doses if needed. Reassess after primidone is stopped.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Atazanavir. The full list is on the Amlodipine-atorvastatin page.
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