Drug interactions
Amlodipine-atorvastatin + Tadalafil
Severity: Moderate
Amlodipine-atorvastatin and Tadalafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tadalafil is a vasodilator that lowers blood pressure and may cause additive hypotension with amlodipine. The effect is usually modest but can cause dizziness or syncope in susceptible patients.
What this interaction means in plain words
Amlodipine-atorvastatin and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-atorvastatin belongs to Cardiovascular; Tadalafil belongs to Genitourinary.
Why it happens
Additive vasodilation from PDE5 inhibition and calcium channel blockade.
What to do
Monitor blood pressure when starting tadalafil, particularly in patients on several antihypertensives. Start with a low dose and counsel on symptoms of hypotension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amlodipine-atorvastatin and Tadalafil, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Amlodipine-atorvastatin
Other interactions of Tadalafil
- Amyl nitrite + Tadalafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
Frequently asked questions
Can I take Amlodipine-atorvastatin with Tadalafil?
MediHelp rates the interaction as moderate. Amlodipine-atorvastatin and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tadalafil is a vasodilator that lowers blood pressure and may cause additive hypotension with amlodipine. The effect is usually modest but can cause dizziness or syncope in susceptible patients.
How serious is the interaction between Amlodipine-atorvastatin and Tadalafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when starting tadalafil, particularly in patients on several antihypertensives. Start with a low dose and counsel on symptoms of hypotension.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Atazanavir. The full list is on the Amlodipine-atorvastatin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
