Drug interactions
Amlodipine-benazepril + Apalutamide
Severity: Moderate
Amlodipine-benazepril and Apalutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide is a strong CYP3A4 inducer and can substantially lower amlodipine concentrations. This may lead to loss of blood pressure control.
What this interaction means in plain words
Amlodipine-benazepril and Apalutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Apalutamide belongs to Endocrine.
Why it happens
Induction of CYP3A4 increases the hepatic and intestinal metabolism of amlodipine, reducing its exposure.
What to do
Monitor blood pressure after starting or stopping apalutamide and increase the amlodipine dose if needed. Consider an alternative antihypertensive if control remains inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Amlodipine-benazepril with Apalutamide?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Apalutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide is a strong CYP3A4 inducer and can substantially lower amlodipine concentrations. This may lead to loss of blood pressure control.
How serious is the interaction between Amlodipine-benazepril and Apalutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after starting or stopping apalutamide and increase the amlodipine dose if needed. Consider an alternative antihypertensive if control remains inadequate.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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