Drug interactions
Amlodipine-benazepril + Apomorphine
Severity: Moderate
Amlodipine-benazepril and Apomorphine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apomorphine commonly causes orthostatic hypotension and syncope, and the effect can be amplified by antihypertensive drugs. Patients taking benazepril and amlodipine may experience symptomatic falls in blood pressure after apomorphine doses.
What this interaction means in plain words
Amlodipine-benazepril and Apomorphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Apomorphine belongs to Central Nervous System.
Why it happens
Additive hypotensive effects from dopaminergic vasodilation and antihypertensive vasodilation or RAAS inhibition.
What to do
Monitor supine and standing blood pressure when starting or titrating apomorphine, and reduce the antihypertensive dose if orthostatic symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Apomorphine
- Alosetron + Apomorphine Contraindicated
- Apomorphine + Cisapride Contraindicated
- Apomorphine + Dolasetron Contraindicated
- Apomorphine + Granisetron Contraindicated
- Apomorphine + Netupitant-palonosetron Contraindicated
- Apomorphine + Ondansetron Contraindicated
Frequently asked questions
Can I take Amlodipine-benazepril with Apomorphine?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Apomorphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apomorphine commonly causes orthostatic hypotension and syncope, and the effect can be amplified by antihypertensive drugs. Patients taking benazepril and amlodipine may experience symptomatic falls in blood pressure after apomorphine doses.
How serious is the interaction between Amlodipine-benazepril and Apomorphine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor supine and standing blood pressure when starting or titrating apomorphine, and reduce the antihypertensive dose if orthostatic symptoms occur.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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