Drug interactions
Amlodipine-benazepril + Aprepitant
Severity: Minor
Amlodipine-benazepril and Aprepitant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aprepitant is a moderate CYP3A4 inhibitor (and mild inducer with longer use) and may raise amlodipine concentrations for a short period. This may cause more vasodilatory effects such as hypotension or edema.
What this interaction means in plain words
Amlodipine-benazepril and Aprepitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-benazepril belongs to Cardiovascular; Aprepitant belongs to Gastrointestinal Tract.
Why it happens
Inhibition of CYP3A4-mediated amlodipine metabolism by aprepitant.
What to do
Monitor blood pressure and edema during aprepitant courses and reduce the amlodipine dose only if symptomatic hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Frequently asked questions
Can I take Amlodipine-benazepril with Aprepitant?
MediHelp rates the interaction as minor. Amlodipine-benazepril and Aprepitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Aprepitant is a moderate CYP3A4 inhibitor (and mild inducer with longer use) and may raise amlodipine concentrations for a short period. This may cause more vasodilatory effects such as hypotension or edema.
How serious is the interaction between Amlodipine-benazepril and Aprepitant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and edema during aprepitant courses and reduce the amlodipine dose only if symptomatic hypotension occurs.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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