Drug interactions
Amlodipine-benazepril + Duloxetine
Severity: Minor
Amlodipine-benazepril and Duloxetine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duloxetine can cause orthostatic hypotension and, less often, raise blood pressure. Combined with antihypertensives, dizziness and falls may occur, especially in older adults.
What this interaction means in plain words
Amlodipine-benazepril and Duloxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-benazepril belongs to Cardiovascular; Duloxetine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic effects on blood pressure and orthostatic tone.
What to do
Monitor blood pressure and orthostatic symptoms when starting duloxetine or adjusting doses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Amlodipine-benazepril with Duloxetine?
MediHelp rates the interaction as minor. Amlodipine-benazepril and Duloxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Duloxetine can cause orthostatic hypotension and, less often, raise blood pressure. Combined with antihypertensives, dizziness and falls may occur, especially in older adults.
How serious is the interaction between Amlodipine-benazepril and Duloxetine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting duloxetine or adjusting doses.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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