Drug interactions
Amlodipine-benazepril + Finerenone
Severity: Moderate
Amlodipine-benazepril and Finerenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benazepril and finerenone each raise serum potassium, so hyperkalemia risk is additive, particularly in patients with renal impairment. Amlodipine is a weak CYP3A4 inhibitor and may modestly increase finerenone exposure, adding to the potassium effect.
What this interaction means in plain words
Amlodipine-benazepril and Finerenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Finerenone belongs to Cardiovascular.
Why it happens
Additive potassium retention from ACE inhibition and mineralocorticoid receptor antagonism, plus weak CYP3A4 inhibition by amlodipine reducing finerenone clearance.
What to do
Check serum potassium and renal function before starting and during treatment. Adjust or withhold the finerenone dose according to potassium levels as set out in its labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Finerenone
- Carbamazepine + Finerenone Contraindicated
- Clarithromycin + Finerenone Contraindicated
- Ensitrelvir + Finerenone Contraindicated
- Finerenone + Itraconazole Contraindicated
- Finerenone + Ketoconazole Contraindicated
- Finerenone + Posaconazole Contraindicated
Frequently asked questions
Can I take Amlodipine-benazepril with Finerenone?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Finerenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Benazepril and finerenone each raise serum potassium, so hyperkalemia risk is additive, particularly in patients with renal impairment. Amlodipine is a weak CYP3A4 inhibitor and may modestly increase finerenone exposure, adding to the potassium effect.
How serious is the interaction between Amlodipine-benazepril and Finerenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and renal function before starting and during treatment. Adjust or withhold the finerenone dose according to potassium levels as set out in its labeling.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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