Drug interactions
Amlodipine-benazepril + Hydrochlorothiazide
Severity: Moderate
Amlodipine-benazepril and Hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an ACE inhibitor with a thiazide diuretic produces additive blood pressure lowering, which is often intended but can cause symptomatic hypotension, especially in volume-depleted patients or at initiation. Renal function may decline and electrolyte disturbances can occur.
What this interaction means in plain words
Amlodipine-benazepril and Hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Diuretic-induced volume and sodium depletion activates the renin-angiotensin system, so ACE inhibition produces an exaggerated fall in blood pressure and reduced glomerular filtration pressure.
What to do
Monitor blood pressure, serum creatinine and electrolytes after starting or adjusting either drug. Correct volume depletion and consider reducing the diuretic dose before initiating the ACE inhibitor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Amlodipine-benazepril with Hydrochlorothiazide?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining an ACE inhibitor with a thiazide diuretic produces additive blood pressure lowering, which is often intended but can cause symptomatic hypotension, especially in volume-depleted patients or at initiation. Renal function may decline and electrolyte disturbances can occur.
How serious is the interaction between Amlodipine-benazepril and Hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and electrolytes after starting or adjusting either drug. Correct volume depletion and consider reducing the diuretic dose before initiating the ACE inhibitor.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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