Drug interactions
Amlodipine-benazepril + Melatonin
Severity: Minor
Amlodipine-benazepril and Melatonin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Melatonin has been reported to raise blood pressure in patients taking dihydropyridine calcium channel blockers, possibly reducing antihypertensive control. The effect is small and inconsistently documented.
What this interaction means in plain words
Amlodipine-benazepril and Melatonin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-benazepril belongs to Cardiovascular; Melatonin belongs to Gastrointestinal Tract.
Why it happens
Mechanism not firmly established; melatonin may modulate vascular tone and oppose calcium channel blocker effects.
What to do
Monitor blood pressure in hypertensive patients who use melatonin regularly. Review melatonin use if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Melatonin
- Fluvoxamine + Melatonin Major
- Alfentanil + Melatonin Moderate
- Belladonna and opium + Melatonin Moderate
- Buprenorphine buccal + Melatonin Moderate
- Butabarbital + Melatonin Moderate
- Butalbital + Melatonin Moderate
Frequently asked questions
Can I take Amlodipine-benazepril with Melatonin?
MediHelp rates the interaction as minor. Amlodipine-benazepril and Melatonin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Melatonin has been reported to raise blood pressure in patients taking dihydropyridine calcium channel blockers, possibly reducing antihypertensive control. The effect is small and inconsistently documented.
How serious is the interaction between Amlodipine-benazepril and Melatonin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure in hypertensive patients who use melatonin regularly. Review melatonin use if control worsens.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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