Drug interactions
Amlodipine-benazepril + Pregabalin
Severity: Moderate
Amlodipine-benazepril and Pregabalin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Angioedema has been reported with pregabalin, and ACE inhibitors are a well-known cause of angioedema. Using both may increase the chance of facial, oral or airway swelling, which can compromise breathing.
What this interaction means in plain words
Amlodipine-benazepril and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Pregabalin belongs to Central Nervous System.
Why it happens
Possible additive angioedema risk; the mechanism for pregabalin is not well established.
What to do
Advise patients to seek urgent care for swelling of the face, tongue or throat. Stop the offending drug and avoid rechallenge if angioedema occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Pregabalin
Frequently asked questions
Can I take Amlodipine-benazepril with Pregabalin?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Angioedema has been reported with pregabalin, and ACE inhibitors are a well-known cause of angioedema. Using both may increase the chance of facial, oral or airway swelling, which can compromise breathing.
How serious is the interaction between Amlodipine-benazepril and Pregabalin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to seek urgent care for swelling of the face, tongue or throat. Stop the offending drug and avoid rechallenge if angioedema occurs.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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