Drug interactions
Amlodipine-benazepril + Rucaparib
Severity: Minor
Amlodipine-benazepril and Rucaparib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib inhibits CYP3A4 to a weak degree and may modestly raise amlodipine concentrations. The clinical effect is usually small, with possible mild hypotension or edema.
What this interaction means in plain words
Amlodipine-benazepril and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-benazepril belongs to Cardiovascular; Rucaparib belongs to Oncology.
Why it happens
Weak CYP3A4 inhibition by rucaparib reduces amlodipine metabolism.
What to do
Monitor blood pressure and edema during rucaparib therapy. Adjust the amlodipine dose only if clinically needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Amlodipine-benazepril with Rucaparib?
MediHelp rates the interaction as minor. Amlodipine-benazepril and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib inhibits CYP3A4 to a weak degree and may modestly raise amlodipine concentrations. The clinical effect is usually small, with possible mild hypotension or edema.
How serious is the interaction between Amlodipine-benazepril and Rucaparib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and edema during rucaparib therapy. Adjust the amlodipine dose only if clinically needed.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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