Drug interactions
Amlodipine-benazepril + Sevoflurane
Severity: Moderate
Amlodipine-benazepril and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Volatile anesthetics such as sevoflurane cause vasodilation and myocardial depression, and the ACE inhibitor and calcium channel blocker in this combination add to the fall in blood pressure. Hypotension during induction and maintenance of anesthesia may be more pronounced.
What this interaction means in plain words
Amlodipine-benazepril and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic hypotensive effects from anesthetic vasodilation plus ACE inhibition and calcium channel blockade.
What to do
Monitor blood pressure closely during anesthesia and have fluids and vasopressors available. Consider holding the ACE inhibitor combination on the morning of surgery per local perioperative protocol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amlodipine-benazepril and Sevoflurane, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Sevoflurane
Frequently asked questions
Can I take Amlodipine-benazepril with Sevoflurane?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Volatile anesthetics such as sevoflurane cause vasodilation and myocardial depression, and the ACE inhibitor and calcium channel blocker in this combination add to the fall in blood pressure. Hypotension during induction and maintenance of anesthesia may be more pronounced.
How serious is the interaction between Amlodipine-benazepril and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure closely during anesthesia and have fluids and vasopressors available. Consider holding the ACE inhibitor combination on the morning of surgery per local perioperative protocol.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
