Drug interactions
Amlodipine-benazepril + Stiripentol
Severity: Moderate
Amlodipine-benazepril and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol affects CYP3A4 activity in both directions, so amlodipine exposure may rise or fall unpredictably. This could cause hypotension and edema or reduced blood pressure control.
What this interaction means in plain words
Amlodipine-benazepril and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Stiripentol belongs to Central Nervous System.
Why it happens
Stiripentol both inhibits and induces CYP3A4, altering amlodipine metabolism.
What to do
Monitor blood pressure and edema when stiripentol is started or stopped. Adjust the amlodipine dose according to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amlodipine-benazepril and Stiripentol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Stiripentol
Frequently asked questions
Can I take Amlodipine-benazepril with Stiripentol?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol affects CYP3A4 activity in both directions, so amlodipine exposure may rise or fall unpredictably. This could cause hypotension and edema or reduced blood pressure control.
How serious is the interaction between Amlodipine-benazepril and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and edema when stiripentol is started or stopped. Adjust the amlodipine dose according to response.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
