Drug interactions
Amlodipine-benazepril + Temsirolimus
Severity: Major
Amlodipine-benazepril and Temsirolimus: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Temsirolimus, an mTOR inhibitor, is associated with angioedema, and the risk appears higher when it is used with an ACE inhibitor such as benazepril. Swelling of the face or airway can be serious.
What this interaction means in plain words
Amlodipine-benazepril and Temsirolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-benazepril belongs to Cardiovascular; Temsirolimus belongs to Oncology.
Why it happens
Additive angioedema risk, as ACE inhibition reduces bradykinin degradation and mTOR inhibitors may further impair its clearance.
What to do
Counsel patients to report swelling of the lips, tongue, face or throat immediately. Stop the ACE inhibitor and switch to another antihypertensive class if angioedema occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Amlodipine-benazepril with Temsirolimus?
MediHelp rates the interaction as major. Amlodipine-benazepril and Temsirolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Temsirolimus, an mTOR inhibitor, is associated with angioedema, and the risk appears higher when it is used with an ACE inhibitor such as benazepril. Swelling of the face or airway can be serious.
How serious is the interaction between Amlodipine-benazepril and Temsirolimus?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to report swelling of the lips, tongue, face or throat immediately. Stop the ACE inhibitor and switch to another antihypertensive class if angioedema occurs.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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