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Drug interactions

Amlodipine-hydrochlorothiazide-valsartan + Amobarbital

Severity: Moderate

Amlodipine-hydrochlorothiazide-valsartan and Amobarbital: moderate interaction.

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For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.

Summary

Barbiturates induce CYP3A4 and can lower amlodipine concentrations, possibly weakening blood pressure control. Barbiturates may also add to orthostatic hypotension caused by the antihypertensive combination and by the diuretic.

What this interaction means in plain words

Amlodipine-hydrochlorothiazide-valsartan and Amobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Amobarbital belongs to Central Nervous System.

Evidence level: Low

Why it happens

Induction of CYP3A4 by amobarbital increases amlodipine metabolism, with additive hypotensive and sedative effects.

What to do

Monitor blood pressure after starting or stopping amobarbital and increase the amlodipine dose if needed. Counsel patients about orthostatic dizziness.

What to ask your pharmacist

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Frequently asked questions

Can I take Amlodipine-hydrochlorothiazide-valsartan with Amobarbital?

MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Amobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates induce CYP3A4 and can lower amlodipine concentrations, possibly weakening blood pressure control. Barbiturates may also add to orthostatic hypotension caused by the antihypertensive combination and by the diuretic.

How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Amobarbital?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after starting or stopping amobarbital and increase the amlodipine dose if needed. Counsel patients about orthostatic dizziness.

What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?

MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.

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