Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Atogepant
Severity: Minor
Amlodipine-hydrochlorothiazide-valsartan and Atogepant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atogepant is a CYP3A4 substrate, and amlodipine is only a weak CYP3A4 inhibitor, so any rise in atogepant exposure is expected to be small and unlikely to matter clinically.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Atogepant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Atogepant belongs to Central Nervous System.
Why it happens
Weak inhibition of CYP3A4 by amlodipine slightly reduces atogepant metabolism.
What to do
No dose adjustment is usually needed; monitor for atogepant adverse effects such as nausea or constipation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Atogepant
- Amobarbital + Atogepant Moderate
- Apalutamide + Atogepant Moderate
- Aprepitant + Atogepant Moderate
- Armodafinil + Atogepant Moderate
- Atogepant + Bosentan Moderate
- Atogepant + Carbamazepine Moderate
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Atogepant?
MediHelp rates the interaction as minor. Amlodipine-hydrochlorothiazide-valsartan and Atogepant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Atogepant is a CYP3A4 substrate, and amlodipine is only a weak CYP3A4 inhibitor, so any rise in atogepant exposure is expected to be small and unlikely to matter clinically.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Atogepant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed; monitor for atogepant adverse effects such as nausea or constipation.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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