Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Avapritinib
Severity: Minor
Amlodipine-hydrochlorothiazide-valsartan and Avapritinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avapritinib is metabolized by CYP3A4, and amlodipine as a weak inhibitor may modestly increase its levels. This could raise the risk of avapritinib adverse effects such as cognitive effects, edema and bleeding.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Avapritinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Avapritinib belongs to Oncology.
Why it happens
Weak CYP3A4 inhibition by amlodipine reduces avapritinib clearance.
What to do
No empiric dose change is required; monitor for avapritinib toxicity, including cognitive symptoms and edema.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Avapritinib
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Avapritinib?
MediHelp rates the interaction as minor. Amlodipine-hydrochlorothiazide-valsartan and Avapritinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Avapritinib is metabolized by CYP3A4, and amlodipine as a weak inhibitor may modestly increase its levels. This could raise the risk of avapritinib adverse effects such as cognitive effects, edema and bleeding.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Avapritinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric dose change is required; monitor for avapritinib toxicity, including cognitive symptoms and edema.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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