Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Bosentan
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Bosentan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan induces CYP3A4 and may lower amlodipine concentrations, reducing blood pressure control. Bosentan also has its own blood pressure lowering effect, so the net effect varies.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Bosentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Bosentan belongs to Miscellaneous.
Why it happens
Bosentan induction of CYP3A4 increases amlodipine metabolism, while both drugs lower blood pressure.
What to do
Monitor blood pressure after starting, adjusting or stopping bosentan, and adjust the amlodipine-containing regimen as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Cyclosporine Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Bosentan?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Bosentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosentan induces CYP3A4 and may lower amlodipine concentrations, reducing blood pressure control. Bosentan also has its own blood pressure lowering effect, so the net effect varies.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Bosentan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after starting, adjusting or stopping bosentan, and adjust the amlodipine-containing regimen as needed.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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