Drug interactions
Azilsartan-chlorthalidone + Calcitriol
Severity: Moderate
Azilsartan-chlorthalidone and Calcitriol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorthalidone reduces urinary calcium excretion, and calcitriol increases calcium absorption, so hypercalcemia can result. Risk is highest with oral calcitriol and higher doses, and much lower with topical use.
What this interaction means in plain words
Azilsartan-chlorthalidone and Calcitriol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azilsartan-chlorthalidone belongs to Cardiovascular; Calcitriol belongs to Musculoskeletal.
Why it happens
Thiazide-like reduced renal calcium excretion combined with vitamin D-driven increased calcium absorption.
What to do
Monitor serum calcium and adjust the calcitriol dose when used orally with chlorthalidone. Topical use over small areas generally needs no action.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azilsartan-chlorthalidone
Other interactions of Calcitriol
- Amlodipine-hydrochlorothiazide-valsartan + Calcitriol Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Calcitriol Moderate
- Amobarbital + Calcitriol Moderate
- Apalutamide + Calcitriol Moderate
- Atazanavir + Calcitriol Moderate
- Atenolol-chlorthalidone + Calcitriol Moderate
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Calcitriol?
MediHelp rates the interaction as moderate. Azilsartan-chlorthalidone and Calcitriol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorthalidone reduces urinary calcium excretion, and calcitriol increases calcium absorption, so hypercalcemia can result. Risk is highest with oral calcitriol and higher doses, and much lower with topical use.
How serious is the interaction between Azilsartan-chlorthalidone and Calcitriol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium and adjust the calcitriol dose when used orally with chlorthalidone. Topical use over small areas generally needs no action.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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