Drug interactions
Amlodipine-perindopril + Calcium gluconate
Severity: Moderate
Amlodipine-perindopril and Calcium gluconate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intravenous calcium gluconate can counteract calcium channel blocker effects and is used to treat overdose. In patients on amlodipine it may reduce the blood pressure lowering effect, but oral use rarely matters.
What this interaction means in plain words
Amlodipine-perindopril and Calcium gluconate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-perindopril belongs to Cardiovascular; Calcium gluconate belongs to Gastrointestinal Tract.
Why it happens
Pharmacodynamic antagonism, because increased extracellular calcium overcomes L-type channel blockade.
What to do
Monitor blood pressure and heart rate during parenteral calcium administration. For oral supplements, monitor serum calcium only.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Calcium gluconate
- Calcium gluconate + Ceftriaxone Contraindicated
- Calcium gluconate + Digoxin Major
- Alendronate + Calcium gluconate Moderate
- Amlodipine-atorvastatin + Calcium gluconate Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Calcium gluconate Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Calcium gluconate Moderate
Frequently asked questions
Can I take Amlodipine-perindopril with Calcium gluconate?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Calcium gluconate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Intravenous calcium gluconate can counteract calcium channel blocker effects and is used to treat overdose. In patients on amlodipine it may reduce the blood pressure lowering effect, but oral use rarely matters.
How serious is the interaction between Amlodipine-perindopril and Calcium gluconate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate during parenteral calcium administration. For oral supplements, monitor serum calcium only.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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