Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Clarithromycin
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Clarithromycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin is a strong CYP3A4 inhibitor and raises amlodipine exposure, which can lead to hypotension, peripheral edema and acute kidney injury. The proposed effect on valsartan transport is of uncertain significance.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Clarithromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Clarithromycin belongs to Anti Bacterial.
Why it happens
Inhibition of CYP3A4-mediated amlodipine metabolism increases amlodipine concentrations.
What to do
Monitor blood pressure and renal function during and shortly after the clarithromycin course, and consider an alternative macrolide such as azithromycin in higher-risk patients. Reduce the amlodipine dose if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Clarithromycin?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Clarithromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clarithromycin is a strong CYP3A4 inhibitor and raises amlodipine exposure, which can lead to hypotension, peripheral edema and acute kidney injury. The proposed effect on valsartan transport is of uncertain significance.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Clarithromycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function during and shortly after the clarithromycin course, and consider an alternative macrolide such as azithromycin in higher-risk patients. Reduce the amlodipine dose if hypotension develops.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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