Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Crizotinib
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Crizotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib is a moderate CYP3A4 inhibitor and may raise amlodipine levels. Crizotinib itself can cause bradycardia, QT prolongation and edema, so additive hypotension and heart rate effects are possible.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Crizotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Crizotinib belongs to Oncology.
Why it happens
Crizotinib inhibition of CYP3A4 reduces amlodipine clearance; pharmacodynamic overlap with its bradycardic effects.
What to do
Monitor blood pressure, heart rate and peripheral edema when crizotinib is started, and reduce the amlodipine dose if hypotension or edema develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Crizotinib?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Crizotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib is a moderate CYP3A4 inhibitor and may raise amlodipine levels. Crizotinib itself can cause bradycardia, QT prolongation and edema, so additive hypotension and heart rate effects are possible.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Crizotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and peripheral edema when crizotinib is started, and reduce the amlodipine dose if hypotension or edema develops.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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