Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Dalteparin
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Dalteparin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Heparins, including low molecular weight heparins, can suppress aldosterone secretion and cause hyperkalemia. When combined with an ARB such as valsartan, which also reduces aldosterone effects, the risk is greater, especially in renal impairment or diabetes.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Dalteparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Dalteparin belongs to Cardiovascular.
Why it happens
Heparin-induced inhibition of adrenal aldosterone synthesis adds to angiotensin receptor blockade, reducing renal potassium excretion.
What to do
Monitor serum potassium and creatinine, particularly with prolonged dalteparin use or reduced renal function. Treat hyperkalemia if it develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Dalteparin?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Dalteparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Heparins, including low molecular weight heparins, can suppress aldosterone secretion and cause hyperkalemia. When combined with an ARB such as valsartan, which also reduces aldosterone effects, the risk is greater, especially in renal impairment or diabetes.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Dalteparin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and creatinine, particularly with prolonged dalteparin use or reduced renal function. Treat hyperkalemia if it develops.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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