Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Dasatinib
Severity: Minor
Amlodipine-hydrochlorothiazide-valsartan and Dasatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dasatinib is a weak-to-moderate inhibitor of CYP3A4 and may modestly raise amlodipine exposure. This could increase vasodilatory effects such as hypotension or peripheral edema, although the effect is usually small.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Dasatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Dasatinib belongs to Oncology.
Why it happens
Dasatinib inhibits CYP3A4-mediated metabolism of amlodipine.
What to do
Monitor blood pressure and for peripheral edema when dasatinib is started or stopped; reduce the amlodipine dose only if hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Dasatinib?
MediHelp rates the interaction as minor. Amlodipine-hydrochlorothiazide-valsartan and Dasatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dasatinib is a weak-to-moderate inhibitor of CYP3A4 and may modestly raise amlodipine exposure. This could increase vasodilatory effects such as hypotension or peripheral edema, although the effect is usually small.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Dasatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and for peripheral edema when dasatinib is started or stopped; reduce the amlodipine dose only if hypotension occurs.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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