Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Eluxadoline
Severity: Minor
Amlodipine-hydrochlorothiazide-valsartan and Eluxadoline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
OATP1B1 inhibitors can raise eluxadoline exposure. Valsartan is not a clinically established OATP1B1 inhibitor at therapeutic doses, so the interaction is largely theoretical.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Eluxadoline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Eluxadoline belongs to Gastrointestinal Tract.
Why it happens
Possible OATP1B1 inhibition reducing eluxadoline hepatic uptake; not well established for valsartan.
What to do
Monitor for eluxadoline adverse effects such as constipation and abdominal pain. No routine dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Eluxadoline
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Eluxadoline?
MediHelp rates the interaction as minor. Amlodipine-hydrochlorothiazide-valsartan and Eluxadoline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. OATP1B1 inhibitors can raise eluxadoline exposure. Valsartan is not a clinically established OATP1B1 inhibitor at therapeutic doses, so the interaction is largely theoretical.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Eluxadoline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for eluxadoline adverse effects such as constipation and abdominal pain. No routine dose change is needed.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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