Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Ethacrynic acid
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Ethacrynic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethacrynic acid is a potent loop diuretic and hydrochlorothiazide is a thiazide, so together they produce additive potassium and magnesium loss and sodium depletion. This may cause hypokalemia, arrhythmias, volume depletion and hypotension. The valsartan component partly offsets potassium loss but does not remove the risk.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Ethacrynic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Ethacrynic acid belongs to Cardiovascular.
Why it happens
Additive renal potassium and sodium wasting from sequential nephron blockade by loop and thiazide diuretics.
What to do
Monitor serum potassium, magnesium, sodium and renal function, especially at initiation and dose changes. Replace electrolytes as needed and watch for volume depletion and hypotension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Ethacrynic acid?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Ethacrynic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ethacrynic acid is a potent loop diuretic and hydrochlorothiazide is a thiazide, so together they produce additive potassium and magnesium loss and sodium depletion. This may cause hypokalemia, arrhythmias, volume depletion and hypotension. The valsartan component partly offsets potassium loss but does not remove the risk.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Ethacrynic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, magnesium, sodium and renal function, especially at initiation and dose changes. Replace electrolytes as needed and watch for volume depletion and hypotension.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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