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Drug interactions

Amlodipine-hydrochlorothiazide-valsartan + Flibanserin

Severity: Moderate

Amlodipine-hydrochlorothiazide-valsartan and Flibanserin: moderate interaction.

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For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.

Summary

Amlodipine is a weak CYP3A4 inhibitor and may increase flibanserin exposure. Flibanserin can cause hypotension, syncope and sedation, and these effects are of greater concern when its levels rise, especially with alcohol.

What this interaction means in plain words

Amlodipine-hydrochlorothiazide-valsartan and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Flibanserin belongs to Genitourinary.

Evidence level: Moderate

Why it happens

Weak inhibition of CYP3A4 by amlodipine reduces the metabolism of flibanserin.

What to do

Counsel the patient about dizziness, sedation and fainting, and advise avoiding alcohol. Monitor blood pressure and reconsider flibanserin if multiple weak CYP3A4 inhibitors are used or symptoms occur.

What to ask your pharmacist

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Frequently asked questions

Can I take Amlodipine-hydrochlorothiazide-valsartan with Flibanserin?

MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amlodipine is a weak CYP3A4 inhibitor and may increase flibanserin exposure. Flibanserin can cause hypotension, syncope and sedation, and these effects are of greater concern when its levels rise, especially with alcohol.

How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Flibanserin?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient about dizziness, sedation and fainting, and advise avoiding alcohol. Monitor blood pressure and reconsider flibanserin if multiple weak CYP3A4 inhibitors are used or symptoms occur.

What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?

MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.

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