Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Fluconazole
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Fluconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole inhibits CYP3A4 and can raise amlodipine concentrations, leading to more hypotension, oedema or dizziness. The effect is usually modest at standard fluconazole doses but can be greater with higher doses.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Fluconazole belongs to Anti Fungals.
Why it happens
Fluconazole inhibition of CYP3A4 decreases amlodipine clearance.
What to do
Monitor blood pressure and for peripheral oedema while fluconazole is taken, and reduce the amlodipine dose if hypotension or adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
- Flibanserin + Fluconazole Contraindicated
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Fluconazole?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole inhibits CYP3A4 and can raise amlodipine concentrations, leading to more hypotension, oedema or dizziness. The effect is usually modest at standard fluconazole doses but can be greater with higher doses.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Fluconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and for peripheral oedema while fluconazole is taken, and reduce the amlodipine dose if hypotension or adverse effects occur.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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