Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Iloperidone
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Iloperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone has alpha-1 adrenergic blocking activity that causes orthostatic hypotension. Combining it with amlodipine, valsartan and hydrochlorothiazide adds to the blood pressure lowering, raising the risk of dizziness, syncope and falls.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Iloperidone belongs to Central Nervous System.
Why it happens
Additive hypotensive effects from alpha-1 blockade by iloperidone and vasodilation, RAS blockade and diuresis from the antihypertensives.
What to do
Monitor blood pressure including orthostatic readings, especially during iloperidone titration. Reduce the antihypertensive dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amlodipine-hydrochlorothiazide-valsartan and Iloperidone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Iloperidone?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone has alpha-1 adrenergic blocking activity that causes orthostatic hypotension. Combining it with amlodipine, valsartan and hydrochlorothiazide adds to the blood pressure lowering, raising the risk of dizziness, syncope and falls.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Iloperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure including orthostatic readings, especially during iloperidone titration. Reduce the antihypertensive dose if symptomatic hypotension occurs.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
