Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Itraconazole
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Itraconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole strongly inhibits CYP3A4 and raises amlodipine exposure, increasing risk of hypotension, edema and reflex tachycardia. Itraconazole also has negative inotropic effects that can add to those of calcium channel blockers and worsen heart failure.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Itraconazole belongs to Anti Fungals.
Why it happens
CYP3A4 inhibition by itraconazole reduces amlodipine clearance, with additive negative inotropy.
What to do
Monitor blood pressure and for peripheral edema or heart failure signs, and reduce the amlodipine dose if needed. Use caution in patients with left ventricular dysfunction.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Itraconazole?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole strongly inhibits CYP3A4 and raises amlodipine exposure, increasing risk of hypotension, edema and reflex tachycardia. Itraconazole also has negative inotropic effects that can add to those of calcium channel blockers and worsen heart failure.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Itraconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and for peripheral edema or heart failure signs, and reduce the amlodipine dose if needed. Use caution in patients with left ventricular dysfunction.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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