Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Labetalol
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Labetalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding labetalol to a three-drug antihypertensive combination produces additive blood pressure lowering, with risk of hypotension, dizziness and bradycardia. The combination is sometimes used intentionally but needs titration.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Labetalol belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic effects from alpha and beta blockade with calcium channel blockade, angiotensin receptor blockade and diuresis.
What to do
Monitor blood pressure and heart rate, titrate doses gradually, and warn patients about orthostatic symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Labetalol?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Adding labetalol to a three-drug antihypertensive combination produces additive blood pressure lowering, with risk of hypotension, dizziness and bradycardia. The combination is sometimes used intentionally but needs titration.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Labetalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, titrate doses gradually, and warn patients about orthostatic symptoms.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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