Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Letermovir
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Letermovir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir can raise exposure to amlodipine and valsartan, and valsartan may in turn raise letermovir levels. The increases are generally modest, but they may produce more hypotension, edema or dizziness.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Letermovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Letermovir belongs to Anti Virals.
Why it happens
Letermovir moderately inhibits CYP3A4 (raising amlodipine) and inhibits OATP1B1/3 (raising valsartan); valsartan may also modestly raise letermovir through OATP1B1/3 inhibition.
What to do
Monitor blood pressure and signs of vasodilation such as peripheral edema after starting or stopping letermovir. Reduce the antihypertensive dose if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amlodipine-hydrochlorothiazide-valsartan and Letermovir, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Letermovir?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Letermovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Letermovir can raise exposure to amlodipine and valsartan, and valsartan may in turn raise letermovir levels. The increases are generally modest, but they may produce more hypotension, edema or dizziness.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Letermovir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and signs of vasodilation such as peripheral edema after starting or stopping letermovir. Reduce the antihypertensive dose if hypotension occurs.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
