Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Lomitapide
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Lomitapide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amlodipine is a weak CYP3A4 inhibitor and may raise lomitapide exposure. Higher lomitapide levels increase the risk of liver enzyme elevation and gastrointestinal adverse effects.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Lomitapide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Lomitapide belongs to Cardiovascular.
Why it happens
Weak inhibition of CYP3A4 by amlodipine reduces the metabolism of lomitapide, a sensitive CYP3A4 substrate.
What to do
Monitor liver enzymes and tolerability and keep the lomitapide dose at the lowest effective level, within the labeled limit for weak CYP3A4 inhibitors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Lomitapide?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Lomitapide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amlodipine is a weak CYP3A4 inhibitor and may raise lomitapide exposure. Higher lomitapide levels increase the risk of liver enzyme elevation and gastrointestinal adverse effects.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Lomitapide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and tolerability and keep the lomitapide dose at the lowest effective level, within the labeled limit for weak CYP3A4 inhibitors.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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