Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Mefenamic acid
Severity: Major
Amlodipine-hydrochlorothiazide-valsartan and Mefenamic acid: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mefenamic acid can blunt the antihypertensive effect of valsartan and hydrochlorothiazide and raises the risk of acute kidney injury and hyperkalemia with an ARB plus diuretic, especially in elderly or volume-depleted patients.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Mefenamic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Mefenamic acid belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandin synthesis causes sodium retention and reduced renal perfusion that is dependent on angiotensin blockade.
What to do
Avoid prolonged use; if needed, use the lowest dose for the shortest time with hydration. Monitor blood pressure, creatinine and potassium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Mefenamic acid
- Ketorolac intranasal + Mefenamic acid Contraindicated
- Ketorolac + Mefenamic acid Contraindicated
- Aceclofenac + Mefenamic acid Major
- Acemetacin + Mefenamic acid Major
- Acetylsalicylic acid + Mefenamic acid Major
- Alteplase + Mefenamic acid Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Mefenamic acid?
MediHelp rates the interaction as major. Amlodipine-hydrochlorothiazide-valsartan and Mefenamic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mefenamic acid can blunt the antihypertensive effect of valsartan and hydrochlorothiazide and raises the risk of acute kidney injury and hyperkalemia with an ARB plus diuretic, especially in elderly or volume-depleted patients.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Mefenamic acid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid prolonged use; if needed, use the lowest dose for the shortest time with hydration. Monitor blood pressure, creatinine and potassium.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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