Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Mefloquine
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Mefloquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mefloquine can cause bradycardia and conduction abnormalities, and may add to the cardiovascular effects of amlodipine. Clinically significant interaction is uncertain and mostly theoretical.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Mefloquine belongs to Anti Parasitic.
Why it happens
Additive effects on cardiac conduction and blood pressure; the proposed pharmacokinetic effect on amlodipine is not well established.
What to do
Monitor heart rate, blood pressure and ECG if symptoms such as palpitations or syncope occur. Consider an alternative antimalarial in patients with conduction disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Mefloquine?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mefloquine can cause bradycardia and conduction abnormalities, and may add to the cardiovascular effects of amlodipine. Clinically significant interaction is uncertain and mostly theoretical.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Mefloquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG if symptoms such as palpitations or syncope occur. Consider an alternative antimalarial in patients with conduction disease.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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