Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Nabumetone
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Nabumetone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as nabumetone can blunt the antihypertensive effect of valsartan and hydrochlorothiazide. Together with a diuretic and an angiotensin receptor blocker, an NSAID raises the risk of acute kidney injury, particularly in elderly or volume-depleted patients, and may cause hyperkalemia.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Nabumetone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Nabumetone belongs to Musculoskeletal.
Why it happens
NSAIDs inhibit renal prostaglandin synthesis, causing sodium and water retention and reduced glomerular perfusion, which counteracts the antihypertensive agents and impairs renal function.
What to do
Use the lowest effective NSAID dose for the shortest time, ensure hydration, and monitor blood pressure, serum creatinine and potassium. Consider paracetamol or another alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Nabumetone
- Ketorolac intranasal + Nabumetone Contraindicated
- Ketorolac + Nabumetone Contraindicated
- Aceclofenac + Nabumetone Major
- Acemetacin + Nabumetone Major
- Acetylsalicylic acid + Nabumetone Major
- Alteplase + Nabumetone Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Nabumetone?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Nabumetone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as nabumetone can blunt the antihypertensive effect of valsartan and hydrochlorothiazide. Together with a diuretic and an angiotensin receptor blocker, an NSAID raises the risk of acute kidney injury, particularly in elderly or volume-depleted patients, and may cause hyperkalemia.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Nabumetone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective NSAID dose for the shortest time, ensure hydration, and monitor blood pressure, serum creatinine and potassium. Consider paracetamol or another alternative.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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