Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Nisoldipine
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Nisoldipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amlodipine and nisoldipine are both dihydropyridine calcium channel blockers. Using them together duplicates therapy and increases the risk of hypotension, edema and reflex tachycardia without a clear benefit.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Nisoldipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Nisoldipine belongs to Cardiovascular.
Why it happens
Duplicate L-type calcium channel blockade gives additive vasodilation.
What to do
Avoid combining two dihydropyridines and stop one. If both are continued, monitor blood pressure and edema closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Nisoldipine
- Itraconazole + Nisoldipine Contraindicated
- Ketoconazole + Nisoldipine Contraindicated
- Apalutamide + Nisoldipine Major
- Carbamazepine + Nisoldipine Major
- Chloramphenicol + Nisoldipine Major
- Clarithromycin + Nisoldipine Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Nisoldipine?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Nisoldipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amlodipine and nisoldipine are both dihydropyridine calcium channel blockers. Using them together duplicates therapy and increases the risk of hypotension, edema and reflex tachycardia without a clear benefit.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Nisoldipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two dihydropyridines and stop one. If both are continued, monitor blood pressure and edema closely.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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