Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Ribociclib
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib is a moderate CYP3A4 inhibitor and may increase amlodipine concentrations. This can cause more hypotension, dizziness and peripheral edema. Ribociclib itself also prolongs the QT interval, which is exacerbated by thiazide-induced hypokalemia.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Ribociclib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated amlodipine metabolism by ribociclib, with additive QT risk if electrolytes are depleted by hydrochlorothiazide.
What to do
Monitor blood pressure and edema and reduce the amlodipine dose if hypotension occurs. Check potassium and magnesium and monitor the ECG as recommended for ribociclib.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Ribociclib?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribociclib is a moderate CYP3A4 inhibitor and may increase amlodipine concentrations. This can cause more hypotension, dizziness and peripheral edema. Ribociclib itself also prolongs the QT interval, which is exacerbated by thiazide-induced hypokalemia.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and edema and reduce the amlodipine dose if hypotension occurs. Check potassium and magnesium and monitor the ECG as recommended for ribociclib.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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